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However, there are dynamic scaffold-based 3D models used to study flow shear stress, such as polydimethylsiloxane (PDMS) only models, and others that combine the hydrogel cell culturing techniques with more complex microfluidic systems, namely PDMS-derived, PDMS-hydrogel hybrids, or pure hydrogel models [259]

This review describes some in vitro models currently under investigation

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When activated by stress-induced hormonal imbalances, these pathways promote the production of pro-inflammatory cytokines and genes associated with oxidative stress, increasing the overall oxidative burden on cells (53)